Never, ever give him ibuprofen again!! It sounds like he does have an allergic response to ibuprofen and a dangerous one at that. Anytime you get swelling in the face, especially around the mouth, there is a danger of swelling in his airway which can be fatal. Prescription Motrin is 800mg of Ibuprofen so that is the equivalent of four of the 200mg Ibuprofen. If you don't break out in a rash or have breathing difficulties after taking one or two Ibuprofen, please don't lose sleep over taking a third. Ibuprofen may cause a rash that has ether flat lesions or small, raised lesions on the skin, according to Drugs.com. There may be red skin lesions, and they may have a purple center. Ibuprofen is an anti-inflammatory and fever-reducing medication. It can be used to treat pain and inflammation associated with many conditions such as menstrual cramps, headaches, arthritis, muscle pain,and toothaches. No: Ibuprofen is a pain reliever has no effect on swelling associated with a poison ivy rash. Over the counter oral antihistamines such as benadryl or cetirizine can relieve some of the inflammation associated with poison ivy rash. Group Calls for Ibuprofen Warnings. Feb. 15, 2005 -- A group of doctors and families called on federal regulators Tuesday to warn the public that Advil and similar drugs can cause rare but. Find information about common, infrequent and rare side effects of Ibuprofen Oral. Altho aspirin, ibuprofen have caused mild hives, i need asp for various reasons. I now medicate daily w/xyzal, za more Altho aspirin, ibuprofen have caused mild hives, i need asp for various reasons. I now medicate daily w/xyzal, zantac (ranitidine). Ibuprofen is an anti-inflammatory and fever-reducing medication. It can be used to treat pain and inflammation associated with many conditions such as menstrual cramps, headaches, arthritis, muscle pain,and toothaches. Applies to ibuprofen: compounding powder, intravenous solution, oral capsule, oral suspension, oral tablet, oral tablet chewable General The most frequently reported adverse effects were gastrointestinal (GI) in nature and included nausea, vomiting, flatulence , and diarrhea.